Apprentice.io's Angelo Stracquatanio on Building Manufacturing AI That Operators Can Trust

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Overview

In this episode of Manufacturing Happy Hour, host Chris Luecke talks with Angelo Stracquatanio, co-founder and CEO of Apprentice.io, about the company's twelve years building software for manufacturing and its newest product, an AI agent called A1. Stracquatanio's position is consistent across the conversation. In manufacturing, humans must stay the driving force, and AI has to be purpose-built, deterministic enough to repeat reliably, and earned through trust rather than hype. Along the way, Stracquatanio covers the company's pivots, its role during COVID, lessons about co-founders and teams, and how Apprentice rebuilt its own operations around AI before asking customers to do the same.

21 min read

Why the Company Is Called "Apprentice"

Asked at the outset why technology should be seen as an apprentice to manufacturing, Stracquatanio explains that the name dates back twelve years. At that time they believed that humans in manufacturing would one day have to work alongside some kind of intelligent tool. They say they had no idea it would turn out to be AI as it exists today. The core belief behind the name, though, has only grown stronger for them: in manufacturing especially, humans remain the driving force and AI is a tool that supports them. In Stracquatanio's view, the name has not only lasted but fits the company's current focus better than ever.

A 200-Page Binder for a Cancer Therapeutic

The company began in pharmaceutical manufacturing because of Stracquatanio's wife, who works in biopharmaceutical (biotech) manufacturing. Twelve years ago the couple lived in Jersey City, and she would come home talking about what had gone wrong at work, which Stracquatanio politely distinguishes from complaining. Her site in New Jersey was running advanced, complex biotech manufacturing of a cancer therapeutic, and the process ran on a 200-page paper binder.

To Stracquatanio, then a software engineer, it seemed absurd that what they assumed was the most cutting-edge kind of facility ran on paper. That pain became the founding premise: bring excellent tools to people on the shop floor so that, ultimately, drug product gets out the door faster. Apprentice now works with manufacturers across many industries, but Stracquatanio stresses that it started with one simple, concrete problem.

From AR Headsets to an Agent Above the Stack

When Luecke asks how the mission has changed since 2014, Stracquatanio says one thing has stayed exactly the same: the company has only ever built tools for people who work in manufacturing. The product portfolio, however, has changed dramatically.

Apprentice started with augmented reality. Google Glass had just come out, and Stracquatanio says they "incorrectly thought" a headset would drive technology change in manufacturing. The reasoning was ergonomic. Workers need both hands, and holding an iPad or using a computer is less natural than wearing a headset. The headsets are still around the office. From there, the company moved into a manufacturing execution system (MES), which grew into a category Apprentice calls a "connected manufacturing network." Apprentice then acquired a manufacturing intelligence company focused on analytics and data processing, built its own edge hardware device to reach level one, and built a laboratory execution system and an L2 automation system. Its newest product is the A1 AI agent, which sits above all of these. Stracquatanio frames the next chapter as the same mission carried out with AI. They hope the company can guide customers through this transition as well.

ISA-95 and Why AI Can't Live in One System

Luecke asks Stracquatanio to explain the ISA-95 standard as if over a beer. Stracquatanio describes manufacturing as having many systems arranged in levels. Level four holds enterprise systems such as the ERP (SAP, NetSuite) and the quality management system, which spans the enterprise. At the site level is the MES, Apprentice's "bread and butter" for over a decade. Below that sit control systems (PLCs, SCADA, the automation stack), and below those, sensor-level data. The hierarchy is also organized by timescale, which Stracquatanio chooses not to get into.

The point Stracquatanio draws from this is that AI built into any single system is "trapped in a box." An AI embedded in the MES can't really interface with the DCS; one in the DCS can't really interface with the ERP. That led Apprentice to build a new layer that is not part of the current standard and that sits above all existing systems. The company is "playing around with" calling it level five, though Stracquatanio wonders aloud whether that goes too far. This layer connects to all four levels, letting one AI and a set of agents tied to people perform tasks across the subsystems.

From Engineer to Wartime CEO, and Back to Writing Code

Asked how they went from software and mobile app developer to entrepreneur, Stracquatanio describes several transitions rather than one. For the first four years, the company was just Stracquatanio and co-founder Gary, who still leads sales. Stracquatanio wrote every line of code and also handled deployments, support, and sales, with everything running on a personal credit card.

After landing the first customers, the pair had to build an actual company. They raised a first round around late 2017 to early 2018, when the team was under about 20 people. Then COVID arrived. Without naming the company, Stracquatanio says Apprentice helped manufacture 300 million doses of a COVID vaccine. The company grew dramatically and raised over $200 million, and Stracquatanio had to shift again from manager to CEO of a multi-product company with layers of management.

Next came what Stracquatanio calls a really big challenge. In 2023 and 2024, the life sciences market, which made up most of Apprentice's revenue at the time, slowed down. Stracquatanio attributes this in part to the Inflation Reduction Act. Because it let the government negotiate drug prices for the first time, Stracquatanio says, it "kind of froze the industry," which didn't know what the change would mean. Stracquatanio describes leading through this period as a "wartime CEO."

Coming out of that, the company ran straight into AI and has focused on it for the past two years. Stracquatanio says the story has come full circle. With A1 they are writing code again and working shoulder to shoulder with the engineers, so they have personally touched anything a customer uses. The moment feels like twelve years ago: new technology, learning on the fly, working directly with customers. Stracquatanio also notes that they didn't come from manufacturing. In the early days they spent literal years in manufacturing suites with customers, "gowned up head to toe" and sweating. Today, Stracquatanio notes, Palantir calls this a forward deployed engineer; back then Stracquatanio just called it learning. Now they are doing the same thing again, because they believe AI can have either a strongly positive or a negative impact and they want to get it right with customers.

"Predict and Prepare": How Apprentice Anticipated COVID

Luecke asks how others can position themselves to capitalize on an opportunity like the one COVID created. Stracquatanio points to an internal operating phrase, "predict and prepare," and a related process called PDS: predict, discuss, and solve. The principle is to always look around the corner. Working in the business is hard, but leaders have to spend as much time working on it, which means keeping a pulse on the market and on how customer concerns keep shifting. By Stracquatanio's count, the company has gone through this cycle of predicting something, aligning the business to it, and capitalizing on it about four or almost five times.

With COVID, in January of that year a team member named Frank, who now hosts Apprentice's weekly podcast, posted an article in Slack about something alarming happening in China. The team discussed it and concluded it could become a real problem. Before travel was shut down, they responded to rumors of travel restrictions by repackaging an existing but minor product, remote telepresence. With it, a worker on the shop floor wears a headset while someone else, possibly in their bedroom, guides them through the process. Apprentice made the product quick to download and start using, so when the pandemic hit it was ready.

Customers used it for the vaccine work itself, which Stracquatanio describes as trying to solve COVID with COVID all around them, and as "kind of scary, honestly." Stracquatanio says an even bigger concern was keeping global operations running. Supply chains were disrupted and people couldn't travel to sites, help colleagues, or troubleshoot in person. The vaccine is the headline, but Stracquatanio says the real stars were customers using these tools to keep drug supply chains open. They also briefly mention "Formula 45s," internal 45-day sprints across the whole business, before moving on.

Complementing Weaknesses and "Molecular-Level Trust"

On building a lasting team, Stracquatanio notes that despite the hard years of 2023–2024, average tenure at Apprentice is approaching four years, which they consider long for a software business. The chief customer officer is coming up on nine years, and some team members have been there ten. Stracquatanio credits two things. The first is the mission: the software is only one piece, and it serves people who build important products for people around the world. The second, which Stracquatanio says they learned through many mistakes, is that the leadership team needs to include people who complement their specific weaknesses.

Stracquatanio describes their younger self as "a pretty awkward dude," a software engineer who "did not know how to sell software, period, full stop." Gary was and remains the perfect complement. Over twelve years they have built what Stracquatanio calls "molecular-level trust": each knows how the other thinks, and conflicts get resolved quickly because they have worked through so many. Similar trust across the wider team means that when a new product launches, Apprentice can pivot the whole business overnight, adopt new tools, change strategy, and work around the clock "with zero drama." Stracquatanio emphasizes that this trust matters for getting through both good times and very tough ones.

Becoming AI-Native Internally: From Quarterly to Weekly Tempo

Asked for advice to manufacturers navigating the AI shift, Stracquatanio starts with their own company. It would be "a bit ridiculous," they say, to tell customers to use a product to become AI-native if Apprentice hadn't done so itself. For more than six months, the company has been going through a major internal transformation across software and operations.

Apprentice used to run on a "quarterly tempo." Every week of the quarter was pre-planned, and teams were coordinated, so that a product release, for example, was matched by marketing and sales webinars and announcements. Stracquatanio says they have compressed what used to take a quarter into a literal week and now run a weekly tempo. They attribute this compression to using agents internally, including A1 itself with agents and workflows built for internal operations. According to Stracquatanio, this cut manual work dramatically, raised people's throughput, and sped up the tempo and "takt time" of the whole business.

The company then overhauled its internal systems, building some tools in-house and upgrading others to new software, with A1 on top. It also changed people's roles. Engineers became "super stack engineers" who work across front end, back end, mobile, and infrastructure, and across business units. Stracquatanio's reasoning is that raising tempo, refocusing people, and using AI for throughput lets Apprentice serve customers better and speak credibly about how to do it. Anything else, they say, would feel hypocritical.

What A1 Is: Agents Mapped to Human Roles

In casual terms, Stracquatanio describes A1 as a new, largely standalone category that sits on top of existing manufacturing systems. A1 has sub-agents mapped to the roles in a manufacturing facility, which reflects what Stracquatanio calls a human-first approach. Examples include operator, quality, process engineering, and maintenance agents, along with an agent Stracquatanio names that is rendered unclearly in the transcript, plus supervisor, leadership, and site planning agents. The agents are meant to complement current workers by automating workflows that are tedious, manual, paper-based, or hard because they span many systems.

Stracquatanio gives two examples. The operator agent can take a set of paper-driven SOPs, find the relevant section when an operator needs to troubleshoot something, and turn it into a clickable, step-by-step troubleshooting guide. Stracquatanio says this goes from paper to a digital procedure "in a couple seconds." The quality agent finds exceptions, does an initial pass on the investigation, and helps the quality leader understand what's happening in the plant and close exceptions faster. The longer-term goal is to automate work across teams, functions, and systems, with the aim of making plants more functional and raising throughput.

Event-Driven, Not a Chatbot: The Alarm Triage Example

Luecke asks for a cross-role scenario. Stracquatanio first notes that teams sit at different points on digital and AI maturity curves. Some will use agents for basic floor-level tasks, while others are ready for advanced workflows. Stracquatanio then stresses that A1 is not a chatbot designed for prompt-and-response. It is meant to react to manufacturing events: alarms, MQTT messages from IoT, material flow, shift-to-shift handoffs, and movement between work cells.

The example is an out-of-the-box alarm triage agent. When an alarm fires, the agent investigates on its own. It pulls the active run from the MES, checks the control system, gathers any events flagged in the IoT publishing system, combines the findings into an analysis, and messages the manufacturing team that the alarm deserves a closer look. Stracquatanio says teams are "truly drowning" in alarms and, unfortunately, often don't look at every one. The agent does the first pass, so humans can decide which alarms need a detailed response, such as ones that might take a process off spec. Teams can start with a role-based agent and progress to trigger-based workflows that span many systems and people, producing outputs Stracquatanio says would be "next to impossible" today.

Constraining a Probabilistic System: Apprentice 4.1 and Structured Workflows

Stracquatanio explains that AI is probabilistic: the same prompt can return different answers. In manufacturing, which requires determinism, repeatability, and consistency, that is a problem. Apprentice constrains the AI in two ways.

The first is its own model. Apprentice fine-tuned a state-of-the-art model on twelve years of the company's knowledge, customer data, and expertise, producing a model it calls Apprentice 4.1. According to Stracquatanio, it gives hyper-specific manufacturing answers rather than general ones and takes compliance requirements and the relevant process into account.

The second is structured workflows inside A1. They follow a step-by-step form familiar to manufacturing: step one, triage; step two, get specific data from the MES; step three, contact the on-call supervisor for the shift. Customers can define their own, and Apprentice ships what Stracquatanio describes as hundreds of out-of-the-box workflows. Users don't have to specify every API endpoint, data point, or analysis. They describe generally what the agent should do, and the strict structure is what Stracquatanio says makes repeatability "shoot through the roof." In their view, that consistency is what allows teams to trust AI on the floor rather than getting different results each time.

What Makes It "Purpose-Built"

Luecke asks directly what makes A1 purpose-built. Stracquatanio walks through the layers. At the model layer, general models like ChatGPT or Claude are trained on broad knowledge and give broad results. Apprentice has used such general models inside its MES for two years and found they gave "general results." To address this, Apprentice used reinforcement learning with domain experts, people with a decade or more of manufacturing experience from both inside and outside the company, to train the model on what good manufacturing output looks like, covering context, data, process, and compliance.

At the agent or "harness" layer, which Stracquatanio describes as the shell around the model that performs actions, Apprentice built a workflow engine designed to connect to manufacturing systems. Stracquatanio contrasts this with OpenAI and Anthropic, which, in their words, want users connecting to generic tools such as monday.com and other collaboration apps. Manufacturing systems live at the lower ISA-95 levels. Apprentice therefore built an on-prem connector that understands those subsystems' data shapes, API endpoints, and data hierarchy.

At the output layer, the connector and agents produce what Apprentice calls manufacturing artifacts: troubleshooting guides, process flow diagrams, SOPs, trend reports, and shift summaries. Stracquatanio argues that manufacturing data is precise, not generic. If AI isn't precise, no one will trust it, and without trust it won't be adopted, which would keep the industry from gaining the benefits Stracquatanio believes it can deliver.

Trust, Credibility, and a Free Tier With No End Date

As the interview winds down, Luecke asks whether trust in AI is moving in the right direction. Stracquatanio answers from experience. Over twelve years, the hardest thing to learn wasn't software, entrepreneurship, or being CEO. It was earning customers' trust. Early on, customers didn't trust Apprentice to run their operations, and Stracquatanio says it took more than a decade to earn the right to run some of the world's most complex manufacturing processes. They expect the same for AI. Adoption won't happen just because it's a buzzword or because a C-suite or board is demanding it. There is, in Stracquatanio's words, "a certain gravity" to earning trust in manufacturing that can't be bypassed.

Apprentice's answer is to lower the barrier to entry. Stracquatanio says the free tier "can do literally everything": it connects to subsystems, includes pre-built agents, and supports MQTT triggers from IoT, all at no cost. It is not a 30-day trial or a limited version. When Luecke calls it a free trial, Stracquatanio corrects this: there's no end date. The reasoning is that manufacturing people need to explore and use a tool themselves before believing anything a vendor says. If a simple use case works, such as uploading some SOPs and getting correct results back, users may gain enough confidence to bring it to their team, then their site, and possibly their enterprise. Stracquatanio also invites feedback directly by email.

Looking Ahead: From Personalized Medicine to Hyper-Personalized Products

For the wild-card question, Stracquatanio shares ideas they describe as "early innings" and admits may sound a bit ridiculous. Some of Apprentice's life sciences customers produce personalized medicine using CRISPR-based technology. Stracquatanio describes it as allowing people, for the first time, to edit their own genes to treat and even cure disease. Manufacturing in this area happens on a one-patient basis, with an entire run for a single person, and Stracquatanio says the company has learned a lot from it.

Stracquatanio believes AI could extend this kind of personalization beyond medicine to products in general, on a per-individual basis, by enabling high-mix manufacturing. They acknowledge this doesn't seem realistic yet, because equipment, processes, and changeovers were designed for something else. Still, they are thinking about a future where manufacturing isn't the same thing made over and over consistently, but "a different thing over and over again consistently." They also mention having strong beliefs and questions about humanoid robots. Despite being a tech person, they say they are "not so hot" on humanoids and that, personally, they don't see them making sense in manufacturing. They leave that topic for another time. The conversation ends on these open questions, with Luecke suggesting they revisit them in a future episode.